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University of Oxford
Royal Society Newton International Fellow
Dr Mandal has developed advanced computational models to predict biocorrosion in magnesium alloy implants, addressing the critical challenge of premature degradation in biological environments. By integrating phase-field fracture modelling with electrochemical corrosion mechanisms, his research provides new insights into corrosion-driven failure processes in bioabsorbable materials.
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The aim of this research has been to advance understanding and predictive modelling of biocorrosion in magnesium (Mg) alloy implants to address their rapid degradation in biological environments. Mg alloys are highly promising bioabsorbable materials for medical implants due to their biocompatibility and mechanical properties. However, their premature biodegradation often results in the implant dissolving before tissue healing is complete, limiting their clinical potential. 

This project developed advanced mechanistic models that integrate the phase field theory of fracture with the electrochemistry of corrosion and film formation. These models shed light on critical processes, such as micro-cracking in magnesium hydroxide films, and how crack progression facilitates further corrosion. 

A significant achievement has been the creation of a scalable, open-source finite element code within the FEniCS framework. The code supports massively parallel computations, enabling efficient large-scale simulations and addressing the limitations of commercial software. 

By combining theoretical insights with computational tools, this research has provided a robust foundation for accelerating the development of reliable and cost-effective Mg alloy-based bioabsorbable implants, paving the way for improved solutions in vascular and orthopaedic medical applications.

This work was conducted in collaboration with Prof. Emilio Martínez-Pañeda (University of Oxford), Dr Sasa Kovacevic (University of Oxford), and Prof. Xavier Llorca (IMDEA Materials Institute, Spain), fostering international partnerships in advancing biomedical materials research.